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pentobarbital will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.pentobarbital will decrease the extent or impact of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Strong CYP3A4 inducers might lower mido